In vivo [Fe-S] cluster acquisition by IscR and NsrR, two stress regulators in Escherichia coli.

@article{Vinella2013InV,
  title={In vivo [Fe-S] cluster acquisition by IscR and NsrR, two stress regulators in Escherichia coli.},
  author={Daniel Vinella and L. Loiseau and Sandrine Ollagnier de Choudens and Marc Fontecave and Fr{\'e}d{\'e}ric Barras},
  journal={Molecular microbiology},
  year={2013},
  volume={87 3},
  pages={493-508}
}
The multi-proteins Isc and Suf systems catalyse the biogenesis of [Fe-S] proteins. Here we investigate how NsrR and IscR, transcriptional regulators that sense NO and [Fe-S] homeostasis, acquire their [Fe-S] clusters under both normal and iron limitation conditions. Clusters directed at the apo-NsrR and apo-IscR proteins are built on either of the two scaffolds, IscU or SufB. However, differences arise in [Fe-S] delivery steps. In the case of NsrR, scaffolds deliver clusters to either one of… CONTINUE READING

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Escherichia coli FNR

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  • J Mol Biol
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