In vivo, in vitro, and in silico analysis of methylation of the HIV-1 provirus.

@article{Chvez2011InVI,
  title={In vivo, in vitro, and in silico analysis of methylation of the HIV-1 provirus.},
  author={Leonard Ch{\'a}vez and Steven E Kauder and Eric Verdin},
  journal={Methods},
  year={2011},
  volume={53 1},
  pages={47-53}
}
HIV-1 latency is a barrier to overcome in the effort to fully eradicate the virus from infected individuals using highly active anti-retroviral therapy (HAART). Therefore, the study of the mechanisms underlying the establishment and maintenance of HIV-1 latency are vital to achieving a cure. Transcriptional repression of the viral promoter is the major cause of HIV-1 latency. DNA methylation of genomic regions known as CpG islands (CpGIs) is a well-established transcriptional regulatory… CONTINUE READING

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