In vitro zonation and toxicity in a hepatocyte bioreactor.

  title={In vitro zonation and toxicity in a hepatocyte bioreactor.},
  author={Jared W. Allen and Salman R Khetani and Sangeeta N. Bhatia},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={84 1},
The complex architecture of the liver is intertwined with its response to xenobiotic compounds. In particular, hepatocyte subpopulations are distributed along the sinusoid in zones 1 to 3, leading to prototypical "periportal" and "centrilobular" patterns of cell death in response to a toxic insult. In vitro models that more closely represent these zones of sub-specialization may therefore be valuable for the investigation of hepatic physiology and pathophysiology. We have established a perfused… CONTINUE READING
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