In vitro uptake of a new cholesteryl carborane ester compound by human glioma cell lines.

@article{Peacock2004InVU,
  title={In vitro uptake of a new cholesteryl carborane ester compound by human glioma cell lines.},
  author={Gina F Peacock and Richard Sidwell and Guangliang Pan and Svein \Ole and D. Robert Lu},
  journal={Journal of pharmaceutical sciences},
  year={2004},
  volume={93 1},
  pages={13-9}
}
The cellular uptake and retention of a new cholesteryl carborane ester compound, cholesteryl 1,12-dicarba-closo-dodecaboranel-carboxylate (BCH), by two human glioma cell lines, glioblastoma multiforme SF-763 and SF-767, was evaluated. BCH, which is an extremely hydrophobic compound, was formulated into liposomes and incubated with two human glioma tumor cell lines and one human normal neuron cell line. The amount of BCH uptake by the cells was measured by high performance liquid chromatography… CONTINUE READING