In vitro toxicity of 1,2-dibromo-3-chloropropane (DBCP) in different testicular cell types from rats.

@article{Bjrge1995InVT,
  title={In vitro toxicity of 1,2-dibromo-3-chloropropane (DBCP) in different testicular cell types from rats.},
  author={C Bj\orge and Richard Wiger and J\orn A Holme and Gunnar Brunborg and Raymond J Andersen and Erik Dybing and Erik Johan S\oderlund},
  journal={Reproductive toxicology},
  year={1995},
  volume={9 5},
  pages={461-73}
}
1,2-Dibromo-3-chloropropane (DBCP)-induced toxicity was studied in rat germ cells from different stages of spermatogenesis, separated by centrifugal elutriation, and in Sertoli cells prepared from sexually mature and immature animals. The in vitro metabolic activation of 50 to 250 microM DBCP, measured as covalent binding of 14C-DBCP to macromolecules, was highest in round spermatids, lowest in Sertoli cells and elongating/elongated spermatids, and intermediate in spermatocytes. High… CONTINUE READING
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