In vitro toxicity evaluation in the development of new anticancer drugs-genistein glycosides.

@article{Popiokiewicz2005InVT,
  title={In vitro toxicity evaluation in the development of new anticancer drugs-genistein glycosides.},
  author={Joanna Popiołkiewicz and Krzysztof Polkowski and Janusz S. Skierski and Aleksander P. Mazurek},
  journal={Cancer letters},
  year={2005},
  volume={229 1},
  pages={67-75}
}
In vitro cytotoxicity tests currently in use applied in the developmental stages of anticancer drug discovery are able to select the most potent compounds, but are not predictive of their potential toxicity. In this study, we have demonstrated the applicability of neutral red uptake assay using mouse fibroblasts Balb/c 3T3 cell line (3T3 NRU assay) for in vitro toxicity testing of newly synthesized genistein glycosides, the compounds that appear to show anticancer activity. We have also proven… CONTINUE READING
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