In vitro thrombolytic efficacy of echogenic liposomes loaded with tissue plasminogen activator and octafluoropropane gas.

@article{Shekhar2017InVT,
  title={In vitro thrombolytic efficacy of echogenic liposomes loaded with tissue plasminogen activator and octafluoropropane gas.},
  author={Himanshu Shekhar and Kenneth B. Bader and Shenwen Huang and T. A. Peng and Shaoling Huang and David D. McPherson and Christy K. Holland},
  journal={Physics in medicine and biology},
  year={2017},
  volume={62 2},
  pages={
          517-538
        }
}
Echogenic liposomes loaded with the thrombolytic recombinant tissue-type plasminogen activator (rt-PA) are under development for the treatment of ischemic stroke. These agents are designed to co-encapsulate cavitation nuclei to promote bubble activity in response to ultrasound exposure, and to enable localized delivery of thrombolytic. Stable cavitation improves the efficacy of the thrombolytic through enhanced fluid mixing. Echogenic liposomes that encapsulate air-filled microbubbles nucleate… CONTINUE READING
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