In vitro therapeutic targeting of neuroblastomas using 125I-labelled meta-iodobenzylguanidine.

@article{Guerreau1990InVT,
  title={In vitro therapeutic targeting of neuroblastomas using 125I-labelled meta-iodobenzylguanidine.},
  author={Dominique Guerreau and Philippe Th{\'e}drez and Pierre Fritsch and Jean Claude Saccavini and Henri M{\'e}tivier and Daniel Nolibe and Roland E. Masse and Sabine Coornaert and J. F. Chatal},
  journal={International journal of cancer},
  year={1990},
  volume={45 6},
  pages={
          1164-8
        }
}
The use of labelled radiopharmaceuticals such as metaiodobenzylguanidine (m-IBG) enables neuroblastomas and other malignant cells from neural crests to be visualized. In vitro study of cellular incorporation into human neuroblastoma lines (SK-N-SH, SK-N-MC, LAN I) showed that only the SK-N-SH line retained iodine-125 m-IBG (125I-m-IBG) significantly. Fifty-five percent of the initial activity was retained after 1 hr incubation at a concentration of 10(-7) M of m-IBG (specific activity: 1,480… CONTINUE READING
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