In vitro tests of 1,3-dithia-2-thioxo-cyclopent-4-ene to evaluate the mechanisms of its hepatoprotective action.
@article{Sadanobu1999InVT, title={In vitro tests of 1,3-dithia-2-thioxo-cyclopent-4-ene to evaluate the mechanisms of its hepatoprotective action.}, author={S Sadanobu and M. Watanabe and C Nakamura and Masakatsu Tezuka}, journal={The Journal of toxicological sciences}, year={1999}, volume={24 5}, pages={ 375-81 } }
Some in vitro tests were performed using 1,3-dithia-2-thioxo-cyclopent-4-ene (DT827A) to evaluate its mode of action on hepatoprotection. Experiments with leucine, uridine and thymidine uptakes using L-132 cells showed no increase in leucine uptake, but did show a tendency toward increases in both uridine and thymidine uptakes, which suggested a stimulating effect on RNA and DNA synthesis in vitro. DT827A did not influence GSH levels in the HepG2 cultured cell system, and did not show…
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References
SHOWING 1-10 OF 16 REFERENCES
Effect of 1,3-dithia-2-thioxo-cyclopent-4-ene and its derivatives on liver injury induced by carbon tetrachloride and orotic acid in rats.
- Chemistry, BiologyThe Journal of toxicological sciences
- 1997
A hepatoprotective potential of theDT827 series compounds was suggested under the conditions of these studies, and DT827B was considered to be the most effective.
Effect of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene on liver injury induced by repeated exposure to galactosamine plus carbon tetrachloride in rats.
- Chemistry, BiologyThe Journal of toxicological sciences
- 1998
A hepatoprotective potential of DT827B was suggested under the conditions of these studies after a therapeutic effect against liver injury induced by D-GalN + CCl4 dose-dependently was suggested.
Effect of diisopropyl 1,3-dithiol-2-ylidenemalonate (NKK-105) on fatty liver induced by carbon tetrachloride.
- Biology, ChemistryJapanese journal of pharmacology
- 1981
The data suggest that NKK-105 exerts a curative effect on CCl4-induced fatty liver by improving the impaired protein synthesis and by promoting lipoprotein secretion.
Inhibition of ethanol-inducible cytochrome P450IIE1 by 3-amino-1,2,4-triazole.
- Biology, ChemistryChemical research in toxicology
- 1990
Results suggest that the inactivation of P450IIE1 may be due to covalent binding of the heme to the protein or the modification of residues near theheme, which prevent substrate interaction.
[Effect of malotilate (diisopropyl 1, 3-dithiol-2-ylidenemalonate) on chronic liver injury caused by carbon tetrachloride].
- MedicineNihon yakurigaku zasshi. Folia pharmacologica Japonica
- 1982
It is difficult to explain the protective effect of malotilate on the liver injury only by this phenomenon, as changes of biochemical parameters and histopathological findings caused by CCl4 were improved thereafter.
Use of linoleic acid radiolysis for assay of antioxidant action of anethole dithiolethione.
- BiologyMethods in enzymology
- 1995
Carbon tetrachloride‐induced lipid peroxidation dependent on an ethanol‐inducible form of rabbit liver microsomal cytochrome P‐450
- Biology, ChemistryFEBS letters
- 1985
Gene damage induced in human alveolar type II (L-132) cells by exposure to dimethylarsinic acid.
- Biology, ChemistryBiochemical and biophysical research communications
- 1993
The results suggest the possibility of DNA-adduct formation at the early period of DMAA exposure in L-132 cells, which is sensitive to ultraviolet irradiation to cause strand breaks.
The uptake of ascorbic acid into human umbilical vein endothelial cells and its effect on oxidant insult.
- BiologyBiochemical pharmacology
- 1995