In vitro testing for anti-inflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donors

@article{Jenny2010InVT,
  title={In vitro testing for anti-inflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donors},
  author={Marcel Jenny and Martin Klieber and Daniela Zaknun and Sebastian Schroecksnadel and Katharina Kurz and Maximilian Ledochowski and Harald Schennach and Dietmar Fuchs},
  journal={Inflammation Research},
  year={2010},
  volume={60},
  pages={127-135}
}
Inflammation is crucially involved in a variety of diseases like autoimmune syndromes, cardiovascular and neurodegenerative disorders, cancer, sepsis and allograft rejection. Freshly isolated human peripheral blood mononuclear cells (PBMCs) are used as a screening assay for anti-inflammatory properties of compounds. Determinations of neopterin production by ELISA and of tryptophan degradation by HPLC are used as read-outs. Results are compared with further markers of immune response and… CONTINUE READING
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Accelerated tryptophan degradation in trauma and sepsis patients is related to pro-inflammatory response and to the diminished in vitro response of monocytes

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