In vitro teratogenic potential of two antifungal triazoles: Triadimefon and triadimenol

@article{Menegola2000InVT,
  title={In vitro teratogenic potential of two antifungal triazoles: Triadimefon and triadimenol},
  author={Elena Menegola and Maria Luisa Broccia and F. Di Renzo and Mariangela Prati and Erminio Giavini},
  journal={In Vitro Cellular & Developmental Biology - Animal},
  year={2000},
  volume={36},
  pages={88-95}
}
The teratogenic potential of two antifungal triazoles (Triadimefon and Triadimenol) has been investigated in vitro by the rat postimplantation whole embryo culture method. Rat embryos 9.5 d old were cultured for 48 h in rat serum with Triadimefon (12.5–250 μM) or Triadimenol (6.25–125 μM) and then examined. Some embryos exposed to Triadimenol (6.25–125 μM) were cultured for 12 extra hours in control serum to improve their developmental degree and then immunostain cranial nerves and ganglia. The… CONTINUE READING

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