In vitro system for high-throughput screening of random peptide libraries for antimicrobial peptides that recognize bacterial membranes.

@article{Xie2006InVS,
  title={In vitro system for high-throughput screening of random peptide libraries for antimicrobial peptides that recognize bacterial membranes.},
  author={Qiuhong Xie and Shigeru Matsunaga and Zhesheng Wen and Setsuko Niimi and Miyuki Kumano and Yoshikiyo Sakakibara and Sachiko Machida},
  journal={Journal of peptide science : an official publication of the European Peptide Society},
  year={2006},
  volume={12 10},
  pages={643-52}
}
Antibacterial peptides have been isolated from a wide range of species. Some of these peptides act on microbial membranes, disrupting their barrier function. With the increasing development of antibiotic resistance by bacteria, these antibacterial peptides, which have a new mode of action, have attracted interest as antibacterial agents. To date, however, few effective high-throughput approaches have been developed for designing and screening peptides that act selectively on microbial membranes… CONTINUE READING