In vitro synergy testing of anidulafungin with itraconazole, voriconazole, and amphotericin B against Aspergillus spp. and Fusarium spp.

Abstract

The in vitro interactions of anidulafungin with itraconazole, voriconazole, and amphotericin B were evaluated by using the checkerboard method. For Aspergillus spp., anidulafungin with amphotericin B showed indifference for 16/26 isolates, while anidulafungin with either azole showed a synergy trend for 18/26 isolates. All drug combinations showed indifference for 7/7 Fusarium sp. isolates.

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@article{Philip2005InVS, title={In vitro synergy testing of anidulafungin with itraconazole, voriconazole, and amphotericin B against Aspergillus spp. and Fusarium spp.}, author={Annie Philip and Zekaver Odabaşi and Jose Ruben Rodriguez and Victor L Paetznick and Enuo Chen and John Rex and Luis L Ostrosky-Zeichner}, journal={Antimicrobial agents and chemotherapy}, year={2005}, volume={49 8}, pages={3572-4} }