In vitro synergistic effects of vinflunine, a novel fluorinated vinca alkaloid, in combination with other anticancer drugs

@article{Barret2000InVS,
  title={In vitro synergistic effects of vinflunine, a novel fluorinated vinca alkaloid, in combination with other anticancer drugs},
  author={J Carl Barret and Chantal Eti{\'e}vant and Bridget T. Hill},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2000},
  volume={45},
  pages={471-476}
}
Purpose: Vinflunine (20′-20′-difluoro-3′,4′-dihydrovinorelbine), a novel derivative of vinorelbine characterized by marked antitumour activity in vivo in a series of experimental murine and human tumours is currently undergoing phase I evaluation. To investigate its potential for inclusion in combination chemotherapy regimens, this preclinical study was undertaken. The in vitro cytotoxicity of vinflunine incubated simultaneously with one of the following drugs was investigated: camptothecin… CONTINUE READING
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