In vitro susceptibility of varicella-zoster virus to acyclovir.

@article{Biron1980InVS,
  title={In vitro susceptibility of varicella-zoster virus to acyclovir.},
  author={Karen K. Biron and Gertrude Bell Elion},
  journal={Antimicrobial agents and chemotherapy},
  year={1980},
  volume={18 3},
  pages={
          443-7
        }
}
The in vitro susceptibility of five strains of varicella-zoster virus to acyclovir was examined by the plaque-reduction method in human diploid lung cells. The 50% effective doses of acyclovir ranged from 2.06 microM to 6.28 microM in a 7-day assay, with a mean of 3.65 microM. Irreversible inhibition of plaque formtation was achieved by drug doses exceeding the 50% effective dose for plaque reduction but nontoxic to the cells. Studies on the relative in vitro susceptibility of varicella-zoster… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 33 CITATIONS

New therapies for human cytomegalovirus infections.

  • Antiviral research
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND

Antiviral drug resistance: mechanisms and clinical implications.

  • Infectious disease clinics of North America
  • 2010
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 19 REFERENCES

Acyclovir kinetics after intravenous infusion

M. J. Doberson, M. Jerkofsky, S. Greer
  • Clin . Pharmacol . Ther .
  • 1979

Inhi - bition of herpes simplex virus - induced DNA polymerase activity and viral DNA replication by 9 - ( 2 - hydroxy - ethoxymethyl ) - guanine and its triphosphate

J. A. Fyfe, P. M. Keller, P. A. Furman, R. L. Miller, G. B. Elion
  • J . Virol .
  • 1979

9 - ( 2 - hy - droxyethoxymethyl ) guanine activity against viruses of the herpes group

S. C. Schimpff, C. L. Fortner, W. H. Greene, P. H. Wiernik
  • Nature ( London )
  • 1978

Deoxypyrimi - dine nucleoside metabolism in varicella - zoster virus - infected cells

M. T. Johnson, J. P. Luby, R. A. Buchanan, D. Mikulec
  • J . Virol .
  • 1978

Similar Papers