In vitro susceptibility of varicella-zoster virus to acyclovir.

@article{Biron1980InVS,
  title={In vitro susceptibility of varicella-zoster virus to acyclovir.},
  author={K. Biron and G. Elion},
  journal={Antimicrobial Agents and Chemotherapy},
  year={1980},
  volume={18},
  pages={443 - 447}
}
  • K. Biron, G. Elion
  • Published 1980
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
The in vitro susceptibility of five strains of varicella-zoster virus to acyclovir was examined by the plaque-reduction method in human diploid lung cells. The 50% effective doses of acyclovir ranged from 2.06 microM to 6.28 microM in a 7-day assay, with a mean of 3.65 microM. Irreversible inhibition of plaque formtation was achieved by drug doses exceeding the 50% effective dose for plaque reduction but nontoxic to the cells. Studies on the relative in vitro susceptibility of varicella-zoster… Expand
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