In vitro susceptibility of breakthrough Candida bloodstream isolates correlates with daily and cumulative doses of fluconazole.

@article{Clancy2006InVS,
  title={In vitro susceptibility of breakthrough Candida bloodstream isolates correlates with daily and cumulative doses of fluconazole.},
  author={Cornelius J. Clancy and Benjamin J. Staley and Minh Hong Nguyen},
  journal={Antimicrobial agents and chemotherapy},
  year={2006},
  volume={50 10},
  pages={3496-8}
}
We determined MICs for 28 Candida isolates recovered from patients who developed breakthrough candidemia while receiving fluconazole. MICs correlated with daily and cumulative doses of fluconazole. Patients receiving > or =2,000 mg cumulatively or >200 mg daily were more likely to be infected with isolates that were not fluconazole susceptible.