In-vitro susceptibility of Giardia lamblia to albendazole, mebendazole and other chemotherapeutic agents.

@article{CedilloRivera1992InvitroSO,
  title={In-vitro susceptibility of Giardia lamblia to albendazole, mebendazole and other chemotherapeutic agents.},
  author={Roberto Cedillo-Rivera and Onofre Mu{\~n}oz},
  journal={Journal of medical microbiology},
  year={1992},
  volume={37 3},
  pages={221-4}
}
The susceptibility of a strain of Giardia lamblia to benzimidazole carbamates, 5-nitroimidazoles, nitrofurans and other drugs was studied in vitro. Albendazole was the most active compound, with a 50% inhibitory concentration (IC50) of 0.01 mg/L and a minimal lethal concentration (MLC) of less than 0.04 mg/L; the IC50 of mebendazole was 0.06 mg/L and the MLC less than 0.5 mg/L. Among the 5-nitroimidazoles tested, ornidazole was the most effective (IC50 0.12 mg/L); tinidazole, metronidazole… CONTINUE READING