In vitro susceptibility of Aspergillus fumigatus to isavuconazole: correlation with itraconazole, voriconazole, and posaconazole.

@article{Gregson2013InVS,
  title={In vitro susceptibility of Aspergillus fumigatus to isavuconazole: correlation with itraconazole, voriconazole, and posaconazole.},
  author={Lea Gregson and Joanne Goodwin and A. Peter Johnson and Laura McEntee and Caroline B. Moore and Malcolm A. Richardson and William W Hope and Susan Julie Howard},
  journal={Antimicrobial agents and chemotherapy},
  year={2013},
  volume={57 11},
  pages={5778-80}
}
Triazoles are first-line agents for treating aspergillosis. The prevalence of azole resistance in Aspergillus fumigatus is increasing, and cross-resistance is a growing concern. In this study, the susceptibilities of 40 A. fumigatus clinical isolates were tested by using the CLSI method with amphotericin B, itraconazole, voriconazole, posaconazole, and the new triazole isavuconazole. Isavuconazole MICs were higher in strains with reduced susceptibilities to other triazoles, mirroring changes in… CONTINUE READING
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