In vitro study of tocolytic effect of rofecoxib, a specific cyclo-oxygenase 2 inhibitor. Comparison and combination with other tocolytic agents.

@article{Doret2002InVS,
  title={In vitro study of tocolytic effect of rofecoxib, a specific cyclo-oxygenase 2 inhibitor. Comparison and combination with other tocolytic agents.},
  author={Muriel Doret and Georges Mellier and M Benchaib and Jean Michel Piacenza and Claude Gharib and Jean Charles Pasquier},
  journal={BJOG : an international journal of obstetrics and gynaecology},
  year={2002},
  volume={109 9},
  pages={983-8}
}
OBJECTIVE The aim of this work was to study and compare the tocolytic effects of rofecoxib with indomethacin, ritodrine, nicardipine and atosiban. We also studied the combination of rofecoxib with each agent. DESIGN In vitro animal experimental study. SETTING Non-selective cyclo-oxygenase (COX) inhibitors have potent tocolytic effect. However, they also have major fetal side effects that seem to be due to COX-1 inhibition. A specific COX-2 inhibitor could be a potent tocolytic agent with… CONTINUE READING