In vitro study of the effect of raloxifene on lipid metabolism compared with tamoxifen.

@article{Hozumi2000InVS,
  title={In vitro study of the effect of raloxifene on lipid metabolism compared with tamoxifen.},
  author={Y. Hozumi and M. Kawano and V. Jordan},
  journal={European journal of endocrinology},
  year={2000},
  volume={143 3},
  pages={
          427-30
        }
}
OBJECTIVE Tamoxifen and raloxifene, selective estrogen receptor modulators, decrease serum concentrations of total cholesterol; however, the effect of these drugs on triglyceride metabolism is unclear. In the present study, we investigated the in vitro effect of raloxifene on lipid metabolism and compared it with that of tamoxifen. DESIGN AND METHODS Intracellular concentrations of total cholesterol and triglyceride in HepG2 cells were measured by an enzymatic method after tamoxifen or… Expand
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