In-vitro study of the activity of ciprofloxacin combined with amikacin or ceftazidime against Pseudomonas aeruginosa.

  title={In-vitro study of the activity of ciprofloxacin combined with amikacin or ceftazidime against Pseudomonas aeruginosa.},
  author={Noha Nagdy Farrag and Justin Bendig and C. A. Talboys and Berge S. Azadian},
  journal={The Journal of antimicrobial chemotherapy},
  volume={18 6},
8 Citations
Synergy and Antagonism of Fluoroquinolones with Other Classes of Antimicrobial Agents
  • H. Neu
  • Biology, Medicine
  • 2012
Current data suggest that the fluoroquinolones are not antagonistic with β-lactams, macrolides, clindamycin and the imidazoles, and in combination with other antimicrobial agents, synergistic and may be useful for treating infections in immunocompromised patients.
Synergy and antagonism of combinations with quinolones
  • H. Neu
  • Biology, Medicine
    European Journal of Clinical Microbiology and Infectious Diseases
  • 2005
Fluoroquinolones should be combined with other agents not to achieve synergy, which is extremely variable, but to provide activity against bacteria inadequately inhibited by the fluoroquolones.
In vitro Interaction between Ofloxacin and Cefotaxime against Gram-Positive and Gram-Negative Bacteria Involved in Serious Infections
The checkerboard method was used to determine the antimicrobial activity of the combination cefotaxime/ofloxacin against 217 bacterial isolates involved in serious infections andagonism was not observed with any of the isolates examined.
Interactions of 4-Quinolones with Other Agents — The Importance in Assessing Practical Antibacterial Potency
The 4-quinolones are broad spectrum antibacterials and therefore are generally used as single antimicrobial agents. However, in certain situations, they can be combined with a second antibacterial to
The New Fluoroquinolones: Correlating in vitro Findings and Clinical Experience
Old controversies concerning the quinolone class of antibiotics were resurrected as the therapeutic potential for the new fluoroquinolones was realized and the mechanism for the antibacterial action of the quInolone was discovered to involve bacterial DNA damage or mutation.
Ciprofloxacin in combination with other antimicrobials.
Ciprofloxacin: Chemistry, Mechanism of Action, Resistance, Antimicrobial Spectrum, Pharmacokinetics, Clinical Trials, and Adverse Reactions
  • M. Lebel
  • Medicine, Biology
  • 1988
Oral and intravenous ciprofloxacin yielded similar clinical and bacteriologic results compared to standard therapy in a wide array of systemic infections, including lower and upper urinary tract infections; gonococcal urethritis; skin, skin structure, and bone infections; and respiratory tract and gastrointestinal tract infections.