In vitro study of axonal migration and myelination of motor neurons in a three-dimensional tissue-engineered model.

@article{Gingras2008InVS,
  title={In vitro study of axonal migration and myelination of motor neurons in a three-dimensional tissue-engineered model.},
  author={Marie Gingras and Marie-Mich{\`e}le Beaulieu and Vicky Chainey Gagnon and Heather D. Durham and François Berthod},
  journal={Glia},
  year={2008},
  volume={56 3},
  pages={
          354-64
        }
}
Primary motor neurons are difficult to study in conventional culture systems because of their short-term survival without trophic support from glia. In addition, axonal migration on a two-dimensional Petri dish does not reflect the three-dimensional (3D) environment in vivo. A unique in vitro 3D model of motor nerve regeneration was developed to study motor neuron axonal migration and myelination. Mouse spinal cord motor neurons were seeded on a collagen sponge populated with Schwann cells and… CONTINUE READING
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