In vitro study of Withanolide D toxicity on goat preantral follicles and its effects on the cell cycle.

@article{Guerreiro2019InVS,
  title={In vitro study of Withanolide D toxicity on goat preantral follicles and its effects on the cell cycle.},
  author={D. D. Guerreiro and L. F. de Lima and Naiza Arc{\^a}ngela Ribeiro de S{\'a} and G. M. Tetaping and B. G. Alves and C. Lobo and Ot{\'i}lia Deusd{\^e}nia Loiola and J. Smitz and J. R. de Figueiredo and Ana Paula Ribeiro Rodrigues},
  journal={Reproductive toxicology},
  year={2019},
  volume={84},
  pages={
          18-25
        }
}
The Withanolide D is a chemotherapeutic potential against the human tumor cell. However, there is no report on the effect of this compound on ovarian function, especially on preantral folliculogenesis. The aim of this study was to evaluate the toxicity of a new candidate to anticancer drug, Withanolide D (WD) on morphologic integrity, development (activation and granulosa cell proliferation) and gene expression of ABCB1 protein of caprine preantral follicles. Ovarian fragments were cultured in… Expand
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