In vitro study and biocompatibility of calcined mesoporous silica microparticles in mouse lung.

@article{AlSalam2011InVS,
  title={In vitro study and biocompatibility of calcined mesoporous silica microparticles in mouse lung.},
  author={Suhail Al-Salam and Ghazala Balhaj and Suleiman Al-Hammadi and Manjusha Sudhadevi and Saeed Tariq and Ankush V Biradar and Tewodros Asefa and Abdul-Kader Souid},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2011},
  volume={122 1},
  pages={86-99}
}
We report on the pneumatocyte structure and function of mouse lung specimens exposed in vitro to two calcined mesoporous silica particles, MCM41-cal (spheres, ∼300 to 1000 nm in diameter) and SBA15-cal (irregular rods averaging ∼500 nm in diameter and ∼1000 nm in length). These mesoporous silica particles are in consideration for potential medical application as delivery vehicles for genes, drugs, and bio-imagers. In the study, lung specimens (about 10 mg each) were excised from male Balb/c… CONTINUE READING