In vitro studies on the OH* and O2(-*) free radical scavenger properties of idebenone in chemical systems.

@article{Semsei1990InVS,
  title={In vitro studies on the OH* and O2(-*) free radical scavenger properties of idebenone in chemical systems.},
  author={I Semsei and Katalin M Nagy and Imre Zs.-Nagy},
  journal={Archives of gerontology and geriatrics},
  year={1990},
  volume={11 3},
  pages={187-97}
}
OH(*) free radicals were generated by Fenton reaction in the presence of bovine serum albumin (BSA). The decreasing water-solubility of BSA with increasing Fe(2+) concentrations of the system is a sensitive indicator of the cross-linking effects of the OH(*) free radicals. Idebenone (oxidized form) was solubilized for this experiment in DMSO and added to the system in final concentrations of 0.01 or 0.1%. Neither of these concentrations displayed any protective effect against the… CONTINUE READING