In vitro studies of human liver alcohol dehydrogenase variants using a variety of substrates.

Abstract

Alcohol dehydrogenase (ADH) is genetically polymorphic, and large differences in allele frequencies exist between the major human races. Genetic variants at the ADH2 gene locus include the beta 2-ADH ("atypical" ADH) present in 85% of Orientals and the beta 1-ADH ("normal" ADH) present in 85 to 95% of whites. Although the presence of one or the other of… (More)

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