In vitro studies of ferritin iron release and neurotoxicity.

  title={In vitro studies of ferritin iron release and neurotoxicity.},
  author={Kay L Double and M Maywald and Michael Schmittel and Peter Franz Riederer and Manfred Gerlach},
  journal={Journal of neurochemistry},
  volume={70 6},
The increase in brain iron associated with several neurodegenerative diseases may lead to an increased production of free radicals via the Fenton reaction. Intracellular iron is usually tightly regulated, being bound by ferritin in an insoluble ferrihydrite core. The neurotoxin 6-hydroxydopamine (6-OHDA) releases iron from the ferritin core by reducing it to the ferrous form. Iron release induced by 6-OHDA and structurally related compounds and two other dopaminergic neurotoxins, 1-methyl-4… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 43 extracted citations

Iron-mediated free radical injury in ethanol-exposed mouse neural crest cells.

The Journal of pharmacology and experimental therapeutics • 2000
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…