In vitro stimulation of Balb/c and C57 BL/6 splenocytes by a recombinantly produced banana lectin isoform results in both a proliferation of T cells and an increased secretion of interferon-gamma.

@article{Stojanovi2010InVS,
  title={In vitro stimulation of Balb/c and C57 BL/6 splenocytes by a recombinantly produced banana lectin isoform results in both a proliferation of T cells and an increased secretion of interferon-gamma.},
  author={Marijana Stojanovi{\'c} and Irena P. Živkovi{\'c} and Vladimir Petru{\vs}i{\'c} and Du{\vs}ko J. Kosec and Rajna Dimitrijevi{\'c} and Ratko M. Jankov and Ljiljana A. Dimitrijevi{\'c} and Marija Gavrovi{\'c}-Jankulovi{\'c}},
  journal={International immunopharmacology},
  year={2010},
  volume={10 1},
  pages={
          120-9
        }
}
Lectins are widely used in many types of assay but some lectins such as banana lectin (BanLec) are recognised as potent immunostimulators. Although BanLec's structure and binding characteristics are now familiar, its immunostimulatory potential has not yet been fully explored. The synthesis by recombinant technology of a BanLec isoform (rBanLec) whose binding properties are similar to its natural counterpart has made it possible to overcome the twin problems of natural BanLec's… Expand
Modulation of functional characteristics of resident and thioglycollate-elicited peritoneal murine macrophages by a recombinant banana lectin
We demonstrated that a recombinant banana lectin (rBanLec), which structural characteristics and physiological impacts highly resemble those reported for its natural counterparts, binds murineExpand
Oral administration of banana lectin modulates cytokine profile and abundance of T-cell populations in mice.
TLDR
The modulation of pro- and anti-inflammatory cytokines and T-cells in the peripheral blood and thymus of mice demonstrated the immunomodulatory properties of natural BanLec in vivo. Expand
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BanLec induced a marked proliferative response in cow and pig PBMC, but was strongest in pigs, where it induced an even higher proliferation rate than Concanavalin A. Expand
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Immunomodulatory Response of Mice Splenocytes Induced by RcaL, a Lectin Isolated from Cobia Fish (Rachycentron canadum) Serum
TLDR
Cytotoxic and immunomodulatory assays with RcaL in mice splenocyte cultures showed that the lectin was not cytot toxic and induced higher interferon gamma and nitric oxide production in splenocytes cultures, suggesting that it acts as an immunommodulatory compound. Expand
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TLDR
It is demonstrated that a dose-dependent stimulation of the colon with rBanLec skewed the immune response towards Th1/Th17 direction and this effect was counterbalanced by the rise in IL-10 production and Qualitative and quantitative characteristics of the established cytokine network were dependent on the applied r BanLec concentration. Expand
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TLDR
This review mainly focuses on mitogenic potential of microbial lectins and will provide a comprehensive view regarding distribution of this remarkable property among microbes including algae, fungi and bacteria, mechanisms and models of mitogenic stimulation, and also assays being employed to detect the mitogenic activity. Expand
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