In vitro skin penetration of griseofulvin in rat and human skin from an ointment dosage form.

@article{Ritschel1988InVS,
  title={In vitro skin penetration of griseofulvin in rat and human skin from an ointment dosage form.},
  author={W. Ritschel and A. S. Zahir Hussain},
  journal={Arzneimittel-Forschung},
  year={1988},
  volume={38 11},
  pages={1630-2}
}
Penetration and permeation of griseofulvin into and across the rat skin after application of three ointment formulations containing either dimethylacetamide (DMAC) or diethylene glycol monoethylether (DGME) or the ointment base alone (control--without DMAC or DGME) were studied, in vitro. Penetration and permeation of griseofulvin into and across the human skin after application of DGME ointment was also studied. Permeation of griseofulvin across the rat skin was highest for the DMAC ointment… CONTINUE READING