In vitro sensitivity to methyl‐prednisolone is associated with clinical response in pediatric idiopathic nephrotic syndrome

@article{Cuzzoni2016InVS,
  title={In vitro sensitivity to methyl‐prednisolone is associated with clinical response in pediatric idiopathic nephrotic syndrome},
  author={Eva Cuzzoni and Sara De Iudicibus and Gabriele Stocco and Diego Favretto and Marco Pelin and Giovanni Messina and Luciana Ghio and Elena Monti and Andrea Pasini and Giovanni Montini and Giuliana Decorti},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2016},
  volume={100}
}
The aim of this study was to evaluate the in vitro steroid sensitivity as a predictor of clinical response to glucocorticoids in childhood idiopathic nephrotic syndrome (INS). Seventy‐four patients (median age 4.33, interquartile range [IQR] 2.82–7.23; 63.5% male) were enrolled in a prospective multicenter study: in vitro steroid inhibition of patients' peripheral blood mononuclear cell proliferation was evaluated by [methyl‐3H] thymidine incorporation assay at disease onset (T0) and after 4… Expand
5 Citations
MIF plasma level as a possible tool to predict steroid responsiveness in children with idiopathic nephrotic syndrome
TLDR
Assessing MIF plasma levels at diagnosis could predict response to glucocorticoids in children with INS, and macrophage migration inhibitory factor (MIF) was a good predictor of steroid response. Expand
Gender May Influence the Immunosuppressive Actions of Prednisone in Young Patients With Inflammatory Bowel Disease
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Investigation of the association of gender and age with GC efficacy and with the expression of Glucocorticoid-Induced Leucine Zipper found older females with IBD have a higher incidence of prednisone unfavorable response and reduced intestinal expression of the GC pharmacodynamic marker GILZ. Expand
Childhood Idiopathic Nephrotic Syndrome: Does the Initial Steroid Treatment Modify the Outcome? A Multicentre, Prospective Cohort Study
TLDR
TTR was not found to be a prognostic factor of relapse; because of this, different steroid regimens, adjusted for TTR, did not modify the relapse rate in any relevant measure and younger age and low total serum protein were independent predictors of relapse risk. Expand
Pharmacology and pharmacogenetics of prednisone and prednisolone in patients with nephrotic syndrome
TLDR
A role for pharmacogenetics to improve individualization of glucocorticoid therapy is suggested and the evidence is limited, but studies in larger cohorts with nephrotic syndrome patients are necessary to draw final conclusions. Expand
Hypomethylation of NLRP3 gene promoter discriminates glucocorticoid‐resistant from glucocorticoid‐sensitive idiopathic nephrotic syndrome patients
TLDR
A new biological mechanism by which patients with INS may acquire GC resistance, that could be used in future as a novel noninvasive diagnostic tool is uncovered. Expand

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