In vitro sensitivity of Plasmodium falciparum clinical isolates from the China-Myanmar border area to quinine and association with polymorphism in the Na+/H+ exchanger.

@article{Meng2010InVS,
  title={In vitro sensitivity of Plasmodium falciparum clinical isolates from the China-Myanmar border area to quinine and association with polymorphism in the Na+/H+ exchanger.},
  author={Hao Meng and Rongping Zhang and Henglin Yang and Qi Fan and Xin-Zhuan Su and Jun Miao and Liwang Cui and Zhao-qing Yang},
  journal={Antimicrobial agents and chemotherapy},
  year={2010},
  volume={54 10},
  pages={4306-13}
}
Quinine resistance (QNR) in Plasmodium falciparum has been detected in many regions of the world where malaria is endemic. Genetic polymorphisms in at least four genes are implicated in QN susceptibility, and their significance often depends on the genetic background of the parasites. In this study, we have culture-adapted 60 P. falciparum clinical isolates… CONTINUE READING