In vitro senescence enhances IL-6 production in human gingival fibroblasts induced by lipopolysaccharide from Campylobacter rectus

@article{Ogura1996InVS,
  title={In vitro senescence enhances IL-6 production in human gingival fibroblasts induced by lipopolysaccharide from Campylobacter rectus},
  author={Naomi Ogura and Utako Matsuda and Fumimaru Tanaka and Yasuko Shibata and Yoshimitsu Abiko},
  journal={Mechanisms of Ageing and Development},
  year={1996},
  volume={87},
  pages={47-59}
}
The production of interleukin-6 (IL-6) in human gingival fibroblasts (Gin cells) is increased by lipopolysaccharide (LPS) from Campylobacter rectus (C. rectus), which is associated with adult periodontitis; however, the age-related changes in the susceptibility of Gin cells to C. rectus LPS remain unclear. We examined the influence of in vitro senescence on C. rectus LPS-stimulated IL-6 production in Gin cells. LPS was prepared from C. rectus ATCC 33238 using hot phenol-water. The Gin cells… CONTINUE READING
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