In vitro selection with artificial expanded genetic information systems.

  title={In vitro selection with artificial expanded genetic information systems.},
  author={Kwame Sefah and Zunyi Yang and Kevin M. Bradley and Shuichi Hoshika and Elizabeth A. Jimenez and Liqin Zhang and Guizhi Zhu and Savita Shanker and Farong Yu and Diane Turek and Weihong Tan and Steven A. Benner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 4},
Artificially expanded genetic information systems (AEGISs) are unnatural forms of DNA that increase the number of independently replicating nucleotide building blocks. To do this, AEGIS pairs are joined by different arrangements of hydrogen bond donor and acceptor groups, all while retaining their Watson-Crick geometries. We report here a unique case where AEGIS DNA has been used to execute a systematic evolution of ligands by exponential enrichment (SELEX) experiment. This AEGIS-SELEX was… CONTINUE READING
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