In vitro selection of the RNA aptamer against the Sialyl Lewis X and its inhibition of the cell adhesion.

@article{Jeong2001InVS,
  title={In vitro selection of the RNA aptamer against the Sialyl Lewis X and its inhibition of the cell adhesion.},
  author={Sujin Jeong and T B Eom and S Kim and Sangwoo Lee and Jaehoon Yu},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={281 1},
  pages={
          237-43
        }
}
Sialyl Lewis X (sLeX) is a tetra-saccharide glycoconjugate of membrane proteins. It acts as a ligand for the selectin proteins during cell adhesion of inflammatory process. Aberrant overexpression of sLeX is also a characteristic of various cancer cells, especially for highly malignant ones. In this paper, the sLeX-specific RNA aptamer was selected using a random RNA library and its affinity and specificity were measured by Surface Plasmon Resonance technique. Affinity of the selected RNA was… CONTINUE READING
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