In vitro selection of structure-switching signaling aptamers.

  title={In vitro selection of structure-switching signaling aptamers.},
  author={Razvan Nutiu and Yingfu Li},
  journal={Angewandte Chemie},
  volume={44 7},
Signaling aptamers are aptamer probes that couple target binding to fluorescent-signal generation. These molecular sensors have potential applications in biosensing, proteomics, and drug discovery. Here we describe a new in vitro selection approach for generating unmodified DNA aptamers that can be immediately transformed into effective signaling probes without the need for further optimization. Standard aptamers can be easily generated by the technique of in vitro selection. However, for… CONTINUE READING
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