In vitro selection of ramR and soxR mutants overexpressing efflux systems by fluoroquinolones as well as cefoxitin in Klebsiella pneumoniae.

@article{BialekDavenet2011InVS,
  title={In vitro selection of ramR and soxR mutants overexpressing efflux systems by fluoroquinolones as well as cefoxitin in Klebsiella pneumoniae.},
  author={Suzanne Bialek-Davenet and Estelle Marcon and V{\'e}ronique Leflon-Guibout and Jean-Philippe Lavigne and Fr{\'e}d{\'e}ric Bert and Richard Moreau and Marie-H{\'e}l{\`e}ne Nicolas-Chanoine},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 6},
  pages={2795-802}
}
The relationship between efflux system overexpression and cross-resistance to cefoxitin, quinolones, and chloramphenicol has recently been reported in Klebsiella pneumoniae. In 3 previously published clinical isolates and 17 in vitro mutants selected with cefoxitin or fluoroquinolones, mutations in the potential regulator genes of the AcrAB efflux pump (acrR, ramR, ramA, marR, marA, soxR, soxS, and rob) were searched, and their impacts on efflux-related antibiotic cross-resistance were assessed… CONTINUE READING
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