In vitro selection of halofantrine resistance in Plasmodium falciparum is not associated with increased expression of Pgh1.

@article{Ritchie1996InVS,
  title={In vitro selection of halofantrine resistance in Plasmodium falciparum is not associated with increased expression of Pgh1.},
  author={G Y Ritchie and Mathirut Mungthin and Jeffrey E. Green and Patrick G. Bray and Shaun R Hawley and Stephen A Ward},
  journal={Molecular and biochemical parasitology},
  year={1996},
  volume={83 1},
  pages={35-46}
}
Recent investigations into quinoline and phenanthrene methanol resistance in Plasmodium falciparum have described a linkage between amplification of the mdr homologue pfmdr1 and decreased susceptibility to mefloquine (MQ) and halofantrine (HF). We have examined the current theories on cross-resistance patterns and pfmdr1 gene expression by comparing the chloroquine (CQ) resistant isolate K1 with K1Hf, developed from the K1 isolate by intermittent exposure to halofantrine. Reduced halofantrine… CONTINUE READING

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