In vitro selection of ceftazidime-avibactam resistance in Enterobacteriaceae with KPC-3 carbapenemase.

@article{Livermore2015InVS,
  title={In vitro selection of ceftazidime-avibactam resistance in Enterobacteriaceae with KPC-3 carbapenemase.},
  author={David Martin Livermore and Marina Warner and Dorota Jamrozy and Shazad Mushtaq and Wright W Nichols and Nazim Mustafa and Neil Woodford},
  journal={Antimicrobial agents and chemotherapy},
  year={2015},
  volume={59 9},
  pages={5324-30}
}
Ceftazidime-avibactam is active against most Enterobacteriaceae isolates with KPC carbapenemases. We investigated whether this activity could be compromised by mutation. Single-step and multistep selections were attempted using ceftazidime-avibactam (avibactam fixed at 1 or 4 μg/ml) versus two strains each of Enterobacter cloacae and Klebsiella pneumoniae, all with the KPC-3 enzyme. Mutant bla KPC alleles were sequenced, and their parentage was confirmed by typing. Ceftazidime-avibactam… CONTINUE READING
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