In vitro selection of DNA-cleaving deoxyribozyme with site-specific thymidine excision activity

@inproceedings{Wang2014InV,
  title={
In vitro selection of DNA-cleaving deoxyribozyme with site-specific thymidine excision activity},
  author={Mingqi Wang and Huafan Zhang and Wei Zhang and Yongyun Zhao and Afshan Yasmeen and Li Zhou and Xiaoqi Yu and Zhuo Tang},
  booktitle={Nucleic acids research},
  year={2014}
}
Single-nucleotide polymorphisms, either inherited or due to spontaneous DNA damage, are associated with numerous diseases. Developing tools for site-specific nucleotide modification may one day provide a way to alter disease polymorphisms. Here, we describe the in vitro selection and characterization of a new deoxyribozyme called F-8, which catalyzes nucleotide excision specifically at thymidine. Cleavage by F-8 generates 3'- and 5'-phosphate ends recognized by DNA modifying enzymes, which… CONTINUE READING
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