In vitro selection and characterization of HCV replicons resistant to multiple non-nucleoside polymerase inhibitors.

@article{Delang2012InVS,
  title={In vitro selection and characterization of HCV replicons resistant to multiple non-nucleoside polymerase inhibitors.},
  author={Leen Delang and Inge Vliegen and Pieter Leyssen and Johan Neyts},
  journal={Journal of hepatology},
  year={2012},
  volume={56 1},
  pages={
          41-8
        }
}
  • Leen Delang, Inge Vliegen, +1 author Johan Neyts
  • Published 2012
  • Medicine, Biology
  • Journal of hepatology
  • BACKGROUND & AIMS To delay or prevent the selection of HCV drug-resistant variants, combination therapy will be needed. Our aim was to determine the antiviral efficacy of various combinations of non-nucleoside polymerase inhibitors (NNI) (that have a different allosteric binding site) and the barrier towards resistance development of such combinations. METHODS Short-term antiviral combination assays were performed in a checkerboard format. Resistance selection experiments employing HCV… CONTINUE READING

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