In vitro selection and characterization of HCV replicons resistant to multiple non-nucleoside polymerase inhibitors.

Abstract

BACKGROUND & AIMS To delay or prevent the selection of HCV drug-resistant variants, combination therapy will be needed. Our aim was to determine the antiviral efficacy of various combinations of non-nucleoside polymerase inhibitors (NNI) (that have a different allosteric binding site) and the barrier towards resistance development of such combinations… (More)
DOI: 10.1016/j.jhep.2011.04.016

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