In vitro-selected linezolid-resistant Mycobacterium tuberculosis mutants.

  title={In vitro-selected linezolid-resistant Mycobacterium tuberculosis mutants.},
  author={Doris Hillemann and Sabine Ruesch-Gerdes and Elvira Richter},
  journal={Antimicrobial agents and chemotherapy},
  volume={52 2},
Development of resistance against linezolid, an alternative drug for the therapy of multidrug-resistant tuberculosis (2), was assessed to be rare (5). We aimed to generate linezolidresistant Mycobacterium tuberculosis strains from 10 different, fully susceptible M. tuberculosis parental strains. Ten linezolidresistant colonies could be isolated from six different parental strains. The frequency of the in vitro appearance of linezolidresistant mutants was 2 10 8 to 5 10 . Previous investigations… CONTINUE READING


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