In vitro screening of traditional South African malaria remedies against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum.

@article{Mokoka2011InVS,
  title={In vitro screening of traditional South African malaria remedies against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum.},
  author={T. Mokoka and Stefanie Zimmermann and Tasqiah Julianti and Y. Hata and N. Moodley and M. Cal and M. Adams and M. Kaiser and R. Brun and N. Koorbanally and M. Hamburger},
  journal={Planta medica},
  year={2011},
  volume={77 14},
  pages={
          1663-7
        }
}
Three hundred extracts were prepared from plants traditionally used in South Africa to treat malaria and screened in vitro for activity against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum. For the 43 extracts which inhibited the growth of one or more parasites to more than 95 % at 9.7 µg/mL, the IC₅₀ values against all four protozoal parasites and cytotoxic IC₅₀s against rat myoblast L6 cells were determined. Amongst the most notable results… Expand
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