In vitro screening and structural characterization of inhibitors of the S100B-p53 interaction.

@article{Wilder2010InVS,
  title={In vitro screening and structural characterization of inhibitors of the S100B-p53 interaction.},
  author={Paul T. Wilder and Thomas H Charpentier and Melissa A Liriano and Kira Gianni and Kristen M. Varney and Edwin V Pozharski and Andrew Coop and Eric A. Toth and Alex D Mackerell and David J. Weber},
  journal={International journal of high throughput screening},
  year={2010},
  volume={2010 1},
  pages={109-126}
}
S100B is highly over-expressed in many cancers, including malignant melanoma. In such cancers, S100B binds wild-type p53 in a calcium-dependent manner, sequestering it, and promoting its degradation, resulting in the loss of p53-dependent tumor suppression activities. Therefore, S100B inhibitors may be able to restore wild-type p53 levels in certain cancers… CONTINUE READING