In vitro schedule-dependency of myelotoxicity and cytotoxicity of Ecteinascidin 743 (ET-743).

  title={In vitro schedule-dependency of myelotoxicity and cytotoxicity of Ecteinascidin 743 (ET-743).},
  author={Michele Ghielmini and Emilia Colli and E. Gadioli Erba and Daniele Bergamaschi and Sandro Pampallona and J. L. Jimeno and Glynn Faircloth and Cristiana Sessa},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  volume={9 9},
BACKGROUND Ecteinascidin (ET-743) is a marine derived compound with an interesting preclinical profile currently completing phase I clinical trials. The present study was undertaken to compare the toxicity of different schedules of ET-743 against human hemopoietic progenitors and tumour cell lines. MATERIALS AND METHODS Human hemopoietic progenitors and solid tumour cell lines were incubated with ET-743 for one hour, 24 hours and one hour daily for five consecutive days to define by… CONTINUE READING
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