In vitro ruminal biotransformation of benzimidazole sulphoxide anthelmintics: enantioselective sulphoreduction in sheep and cattle.

@article{Virkel2002InVR,
  title={In vitro ruminal biotransformation of benzimidazole sulphoxide anthelmintics: enantioselective sulphoreduction in sheep and cattle.},
  author={Guillermo L Virkel and Adri{\'a}n Luis Lifschitz and Alejandra Pis and Carlos E. Lanusse},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={2002},
  volume={25 1},
  pages={15-23}
}
The comparative in vitro sulphoreduction of the (+) and (-) enantiomers of albendazole sulphoxide (ABZSO) and oxfendazole (OFZ) by ruminal fluid obtained from sheep and cattle, was investigated, under anaerobic conditions, in this study. Ruminal fluid samples were obtained from Holstein steers fitted with a permanent rumen fistula and from Corriedale lambs via an oesophageal tube. Albendazole sulphoxide, incubated as either the racemic (rac) mixture or as each individual enantiomeric form, was… CONTINUE READING