In vitro responsiveness of human asthmatic bronchus to carbachol, histamine, beta-adrenoceptor agonists and theophylline.

@article{Goldie1986InVR,
  title={In vitro responsiveness of human asthmatic bronchus to carbachol, histamine, beta-adrenoceptor agonists and theophylline.},
  author={Roy G. Goldie and Domenico Spina and Peter J. Henry and K. M. Lulich and J. W. Paterson},
  journal={British journal of clinical pharmacology},
  year={1986},
  volume={22 6},
  pages={669-76}
}
Responses of human bronchial strip preparations to contractile and relaxant agonists were measured in preparations from non-diseased and from asthmatic lung obtained 3-15 h post-mortem. The potencies of carbachol and histamine were approximately two times less in asthmatic than in non-diseased bronchi. This was statistically significant for carbachol (P less than 0.05), but not for histamine (P greater than 0.05). These results clearly indicate that the bronchial hyperreactivity to airway… CONTINUE READING
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