In vitro response of Escherichia coli to antibiotics and ultrasound at various insonation intensities.

@article{Williams1997InVR,
  title={In vitro response of Escherichia coli to antibiotics and ultrasound at various insonation intensities.},
  author={Richard G Williams and William G. Pitt},
  journal={Journal of biomaterials applications},
  year={1997},
  volume={12 1},
  pages={20-30}
}
Microbial infections on implanted medical devices are difficult to treat. Application of 70 kHz ultrasonic irradiation to gentamicin treatment greatly enhanced the action of the antibiotic in terms of reduced viable bacterial concentrations. Ultrasonic irradiation was carried out at various insonation intensities that were noninhibitory in the absence of antibiotic. Synergistic killing was observed to be a function of ultrasonic intensity. Greatest killing (approximately 5 log reduction in… CONTINUE READING