In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

@article{Wernig2007InVR,
  title={In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state},
  author={M. Wernig and A. Meissner and R. Foreman and T. Brambrink and Manching Ku and K. Hochedlinger and B. Bernstein and R. Jaenisch},
  journal={Nature},
  year={2007},
  volume={448},
  pages={318-324}
}
Nuclear transplantation can reprogramme a somatic genome back into an embryonic epigenetic state, and the reprogrammed nucleus can create a cloned animal or produce pluripotent embryonic stem cells. One potential use of the nuclear cloning approach is the derivation of ‘customized’ embryonic stem (ES) cells for patient-specific cell treatment, but technical and ethical considerations impede the therapeutic application of this technology. Reprogramming of fibroblasts to a pluripotent state can… Expand

Paper Mentions

Interventional Clinical Trial
The investigators plan to obtain skin and blood samples from healthy volunteers and patients with a benign, inherited hematologic disease to use for research to use homologous… Expand
ConditionsAnemia, Sickle Cell
InterventionProcedure
Stem cells and nuclear reprogramming
  • T. Šarić, J. Hescheler
  • Biology, Medicine
  • Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy
  • 2008
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Generation of human induced pluripotent stem cells from dermal fibroblasts
Generation of induced pluripotent stem cells in the absence of drug selection.
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Chromatin signatures of pluripotent cell lines
ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable.
Nuclear reprogramming and pluripotency
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