In vitro release test system of (d,l-lactic-glycolic) acid copolymer microcapsules for sustained release of LHRH agonist (leuprorelin)

@inproceedings{Kamijo1996InVR,
  title={In vitro release test system of (d,l-lactic-glycolic) acid copolymer microcapsules for sustained release of LHRH agonist (leuprorelin)},
  author={Akiko Kamijo and Shigeru Kamei and Akira Saikawa and Yasutaka Higashinada-ku Igari and Yasuaki Ogawa},
  year={1996}
}
Release of leuprorelin, an LHRH agonist, from injectable microcapsules and degradation of its biodegradable polymer [(d,l-lactic-glycolic) acid copolymer: PLGA] matrix were investigated to optimize an in vitro release test system and to clarify the difference between the in vivo release and in vitro release test system. Many factors such as pH, salt concentration and osmolarity of dispersion medium changed drug release. Weight loss along with the decrease of the molecular weight of PLGA was… CONTINUE READING