In vitro release of trypanocidal drugs from biodegradable implants based on poly(epsilon-caprolactone) and poly(D,L-lactide).

@article{Lemmouchi1998InVR,
  title={In vitro release of trypanocidal drugs from biodegradable implants based on poly(epsilon-caprolactone) and poly(D,L-lactide).},
  author={Y Lemmouchi and Etienne H Schacht and C Lootens},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={1998},
  volume={55 1},
  pages={79-85}
}
In this study, commercial available poly(epsilon-caprolactone)s and poly(d,l-lactide)s of different molecular masses were used. Slow release devices (SRD) were obtained as rods of suitable diameters by extrusion of polymer-drug mixtures (75:25, w/w) which were prepared by the solution casting method. The rods were coated by dipping them in a methylene chloride solution of the core polymer. The in vitro release of the selected drugs, isometamidium chloride (IMM) and ethidium bromide (EtBr) from… CONTINUE READING